Papers in peer reviewed journals
2011
Function of Plectranthus barbatusherbal tea as neuronal acetylcholinesterase inhibitor.
P. L. V. Falé, P. J. A. Madeira, M. H. Florêncio, L. Ascensão, M. L. M. Serralheiro.
Food and Function, 2011, doi: 10.1039/c0fo00070a
Stability and enzymatic studies with omeprazole: hydroxypropyl-b-cyclodextrin.
M. Ramos, P. Salústio, L. Serralheiro, F. Fazão, H. Marques.
J Incl Phenom Macrocycl Chem, 2011, doi: 10.1007/s10847-010-9884-3.
Bifunctional phenolic-choline conjugates with potential neuroprotective roles; antioxidant and antiacetylcholinesterase activities.
J. Šebestík, S.M. Marques, P.L. Falé, S. Santos, D.M. Arduíno, S. M. Cardoso,, C. R. Oliveira, M. L.M. Serralheiro, M. A. Santos,
Journal of Enzyme Inhibition and Medicinal Chemistry, 2011, doi: 10.3109/14756366.2010.529806
Effects of methanol extracts of Plectranthus barbatus and Plectranthus ecklonii on the viability, in suspension and biofilms, and virulence factors of Streptococcus sobrinus and Streptococcus mutants.
N. L. Figueiredo, P. L. Falé, P. J. A. Madeira, M. H. Florêncio, L. Ascensão, M. L. M. Serralheiro, A. R. Lino.
Archives of Oral Biology. 2011 (in press).
Novel sulfenamides as promising acetylcholinesterase inhibitors.
C. Proença, M.L.M.Serralheiro, M.E.M.Araújo, M.T.Pamplona, S. M. Santos, M. Soledade C. S. Santos, F.Norberto Frazão..
Journal of Heterocyclic Chemistry, 2011 (in press).
2010
Chlorogenic acid, hyperoside, isoquercitrin, quercitrin and rutin, are the compounds responsible for acetylcholinesterase inhibition and antioxidant activity of several water extracts of Hypericum species.
M. F. Hernandez, P. V. Falé, M. E. M. Araújo, M. L. M. Serralheiro.
Food Chemistry, 2010, 120, 1076-1082,
The Inhibitory Effect of Plectranthus barbatus and Plectranthus ecklonii Leaves on the Viability; Glucosyltransferase Activity and Biofilm Formation of Streptococcus sobrinus and Streptococcus mutans.
N. L. Figueiredo, S. R. M. M. Aguiar, P. L. Falé, L. Ascensão, M. L. M. Serralheiro, A. R. Lino.
Food Chemistry, 2010, 119, 664-668.
Antiacetylcholinesterase and antioxidant activities of Plectranthus barbatus tea after in vitro gastro-intestinal metabolism.
S. Porfírio, P. L. V. Falé, P. Madeira, M. H. Florêncio, L. Ascensão, M. L. M. Serralheiro.
Food Chemistry, 2010, 122, 179-187.
Preparation and physicochemical characterization of Ag nanoparticles biosynthesized by Lippia citriodora (Lemon Verbena).
Diana Cruz; Pedro L Falé; Ana Mourato; Pedro D Vaz; M. L. Serralheiro; A. R. Lino. Colloids and Surfaces B: Biointerfaces, 2010, 81, 67-73.
2009
Plant Extracts with Anti-inflammatory Properties – A New Approach for Characterization of their Bioactive Compounds and Establishment of Structure-Antioxidant Activity Relationships.
S. Amaral, L. Mira, J. M. F. Nogueira, A. P. Silva, M. H. Florêncio.
Bioorganic and Medicnal Chemistry, 2009, 17, 1876-1883.
Structure and Antioxidant activity of Brominated Flavonols and Flavanones.
G. Justino, M. Rodrigues, M. H. Florêncio, L. Mira
Journal of Mass Spectrometry, 2009, 44, 1459-1468.
Elemental Composition of Cephalopods from Portuguese Continental Waters.
H. M. Lourenço, P. Anacleto, C. Afonso, V. Ferraria, M. F. Martins, M. L. Carvalho, A. R. Lino, M. L. Nunes.
Food Chemistry, 2009, 113, 1146-1153.
Bioactivity Studies and Chemical Profile of the Antidiabetic Plant Genista tenera.
A. P. Rauter, A. Martins, R. Lopes, J. Ferreira, L. M. Serralheiro, M.-E. Araújo, C. Borges, J. Justino, F. V. Silva, M. Goulart, J. Thomas-Oates, J. A. Rodrigues, E. Edwards, J. P. Noronha, R. Pinto, H. Mota-Filipe.
J. Ethnopharmacology, 2009, 122, 384-393.
Rosmarinic Acid, Scutellarein 4'-methyl ether 7-O-glucuronide and (16S)-Coleon E are the Main Compounds Responsible for the Antiacetylcholinesterase and Antioxidant Activity in Herbal Tea of Plectranthus barbatus (“Falso Boldo”).
P. Falé, C. Borges, Paulo J. Amorim Madeira, L. Ascensão, M. E. M. Araújo, M. H. Florêncio, M. L. M. Serralheiro.
Food Chemistry, 2009, 114, 798-805.
Substrate Interaction with Recombinant Amidase from Pseudomonas aeruginosa During Biocatalysis
R. Pacheco, A. Karmali, M. L. M. Serralheiro, P. I. Haris
Biocatalysis and Biotransformation, 2009, 27, 367-376.
Antioxidant, Antiacetylcholinesterase and Antimicrobial Activities of Cymbopogon Schoenanthus L: Spreng (Lemon Grass) from Tunisia.
A.Khadri, M. Neffati, S. Smiti, P. Falé, A.R. Lino, M.L. Serralheiro, M.E. M. Araújo.
Food Science and Technology, 2009, 43, 331-336.
Chemical Characterization of Nephrops novergicus from Portuguese Coast.
H. Lourenço, P. Anacleto, C. Afonso, M. F. Martins, M. L. Carvalho, A. R. Lino, M. L. Nunes.
Journal of the Science Food and Agriculture, 2009, 89, 2572-2580.
2008
Influence of the Metabolic Profile on the in Vivo Antioxidant Activity of Quercetin under a Low Dosage Oral Regimen
M. R. Santos, M. J. Rodríguez-Gómez, G. C. Justino, N. Charro, M. H. Florêncio, L. Mira
British Journal of Pharmacology 2008, 153, 1750-1761.
Molecular Mechanisms of Anti-Inflammatory Activity Mediated by Flavonoids
A. Gomes, E. Fernandes, J. L. F. C. Lima, L. Mira, M. L. Corvo
Current Medicinal Chemistry, 2008, 15, 1586-1605.
Antioxidant and antiacetylcholinesterase activities of essential oils from Cymbopogon schoenanthus L. Spreng. Determination of chemical composition by GC-mass spectrometry and 13C-NMR.
A.Khadri, M.L.M.Serralheiro, J.M.F. Nogueira, M. Neffati, S.Smiti and M.E.M.Araújo.
Food Chemistry, 2008, 108, 630-637.
2007
NADH Oxidase Activity of Rat and Human Liver Xanthine Oxidoreductase: Potential Role in Superoxide Production
L. Maia, R. O. Duarte, A. Ponces-Freire. J. J. G. Moura, L. Mira.
Journal of Biological Inorganic Chemistry 2007, 12, 777-787.
Antioxidant and Antiacetylcholinesterase Activities of Five Plants used as Portuguese Food Spices
A. T. Mata, C. Proença, A. R. Ferreira, M. L. M. Serralheiro, J. M. F. Nogueira, M. E. M. Araújo.
Food Chemistry, 2007, 103, 778-786.
Monoclonal Antibodies Recognize Conformational Epitopes on Wild-type and Recombinant Mutant Amidases from Pseudomonas aeruginosa.
S.Martins, S.Lourenço, A.Karmali, M.L.Serralheiro.
Molecular Biotechnology, 2007, 37, 136-145.
2006
The Antioxidant Activity of a Catechol Derived from Abietic Acid.
G. C. Justino, C. F. Correia, L. Mira, R. M. Borges dos Santos, J. A. Martinho Simões, A. M. Silva, C. Santos, B. Gigante.
Journal of Agricultural and Food Chemistry 2006, 54, 342-348.
The in vitro Screening for Acetylcholinesterase Inhibition and Antioxidant Activity of Medicinal Plants from Portugal.
A. Ferreira, C. Proença, M. L. M. Serralheiro, M. E. M. Araújo.
Journal of Ethnopharmacology, 2006, 108, 31-37.
Screening of Suitable Immobilized Metal Chelates for Adsorption of Monoclonal Antibodies against Mutant Amidase Pseudomonas aeruginosa.
S.Martins, J. Andrade, A. Karmali, M.L. Serralheiro.
Journal of Molecular Recognition, 2006, 19, 340-347.
Kinetic Properties of Wild-type and Altered Recombinant Amidases by the Use of Ion-selective Electrode Assay Method.
S.Martins, A.Karmali and M.L.Serralheiro.
Analytical Biochemistry, 2006, 355, 232-239.
Desulfovibrio Gigas: Toxicity of Copper and Molybdenium,
A. R. Lino, C. R. Farinha, S. Pereira, S. A. Bursakov
Metal Ions in Biology and Medicine 2006, 9, 231-235.
2005
NADH Oxidase Activity of Rat Liver Xanthine Dehydrogenase and Xanthine Oxidase - Contribution for Damage Mechanisms.
L. Maia, A. Vala, L. Mira.
Free Radical Research 2005, 39, 979-986.
Characterization of Monoclonal Antibodies Against Altered (T103I) Amidase from Pseudomonas aeruginosa.
S. Martins, A. Karmali, J. Andrade, A. Custódio, M. L. Serralheiro.
Molecular Biotechnology ,2005, 30, 207-219.
Biological Sulphate Reduction and Redox Mediator Effects on Azo Dye Decolourisation in Anaerobic-Aerobic Sequencing Batch Reactors.
M. G. E. Albuquerque, A. T. Lopes, M. L. M. Serralheiro, J. M. Novais, H. M. Pinheiro.
Enzyme and Microbial Technology, 2005, 36, 790-799.
Application of FTIR Spectroscopy for Monitoring Hudrolysis and Synthesis Reactions Catalysed by a Recombinant Amidase.
R. Pacheco, A. Karmali, M. L. M. Serralheiro, P. I. Harris.
Analytical Biochemistry, 2005, 346, 49-58.
Amidase Encapsulated in TTAB Reversed Micelles for the Study of Transamidation Reactions.
R. Pacheco, A. Karmali, M. L. M. Serralheiro.
Biocatalysis & Biotransfromation, 2005, 23, 407-414.
2004
Protection by Flavonoids Against the Peroxynitrite-mediated Oxidation Dihydrhodamine.
M. R. Santos, L. Mira.
Free Radical Research 2004, 38, 1011-1018.
Plasma Quercetin Metabolites: Structure-Antioxidant Activity Relationships.
G. C. Justino, M. R. Santos, S. Canário, C. Borges, M. H. Florêncio, L. Mira.
Archives of Biochemistry and Biophysics 2004, 432, 109-121.
Levels of Toxic Metals in Canned Seafood.
H. M. Lourenço, C. Afonso, M. F. Martins, A. R. Lino, M. L. Nunes.
Journal of Aquatic Food Product Tecnology, 2004, 13, 117-125.
2003
Development of a New Amperometric Biosensor for Lactose Determination.
R. J. M. Lourenço, M. L. M. Serralheiro, M. J. Rebelo.
Portugalia Electrochimica Acta, 2003, 21, 171-177.
Measuring Enzymatic Activity of a Recombinant Amidase using Fourier Transform Infrared Spectroscopy.
R. Pacheco, M. L. M. Serralheiro, A. Karmali, P. I. Harris.
Analytical Biochemistry, 2003, 322, 208-214.
2002
Xanthine Oxidase and Aldehyde Oxidase: A Simple Procedure for the Simultaneous Purification from Rat Liver.
L. Maia, L. Mira.
Archives of Biochemistry and Biophysics 2002, 400, 48-53.
Iron and Copper Chelation by Flavonoids – An Electrospray Mass Spectrometry Study.
M. T. Fernandez, M. L. Mira, M. H. Florêncio, K. R. Jennings.
Journal of Inorganic Biochemistry 2002, 92, 105-111.
Structure-Antioxidant Activity Relationships of Flavonoids: A Re-examination.
M. M. Silva, M. R. Santos, G. Caroço, R. Rocha, G. Justino, L. Mira.
Free Radical Research 2002, 36, 1219-1227.
Interactions of Flavonoids with Iron and Copper Ions: A Mechanism for their Antioxidant Activity.
L. Mira, M. T. Fernandez, M. Santos, R. Rocha, M. H. Florêncio, K. R. Jennings.
Free Radical Research 2002, 36, 1199-1208.
Anaerobic Reduction of a Sulfonated Azo Dye, Congo Red, by Sulfate Reducing Bacteria.
P. E. Diniz, A. T. Lopes, A. R. Lino, M. L. M. Serralheiro.
Applied Biochemistry & Biotechnology , 2002, 97, 147-163.
Study of the Stability of Vaccinium Myrtillus Peroxidases in Reversed Micellar Systems.
A. J. E. Pedro, P. S. Fevereiro, M. L. M. Serralheiro, M. R. Aires-Barros.
Biocatalysis and Biotransformation, 2002, 20, 129-135.
Anaerobic Redution of a Sulfonated Azo Dye, Congo Red, By Sulfate Reducing Bacteria.
P. E. Diniz, A. T. Lopes, A. R. Lino, M. L. M. Serralheiro.
Applied Biochemistry and Biotechnology, 2002, 97, 147-163.
2001
Development of a New Amperometric Biosensor Based on Polyphenoloxidase and Ployethersulphone Membrane.
P. V. Climent, M. L. M. Serralheiro, M. J. F. Rebelo.
Pure & Applied Chemistry, 2001, 73, 1-7.
2000
Antioxidants in Medicinal Plant Extracts. A Research Study of the Antioxidant Capacity of Crataegus, Hamamelis and Hydrastis.
A. P. Silva, R. Rocha, C. L. Silva, L. Mira, M. F. Duarte, M. H. Florêncio.
Phytotherapy Research 2000, 13, 612-618.
Study of the Effects of Dietary Fish Intake on Serum Lipids and Lipoproteins in Two Populations with Different Dietary Habits.
I. Torres, L. Mira, C. Ornelas, A. Melim.
British Journal of Nutrition 2000, 83, 371-379.
Comparative Study of Sulphate Reducing Bacteria.
A. S. Martins, P. Nicolau, M. Meireles, A. R. Lino.
Microbial Corrosion 2000, 29, 61-68.
The Influence of the Desulfovibrio desulfuricans ATCC 27774 on the Corrosion of Mild Steel.
M. J. Feio, V. Rainha, M. A. Reis, A. R. Lino, I. T. Fonseca.
Materials and Corrosion 2000, 51, 691-697.
National Patent
Processo para produção contínua de cristais dipéptidos num reactor de hidrociclone e membrana via síntese enzimática e cristalização simultânea em sistemas de micelas invertidas.
D. M. F. Prazeres, A. I. Dias, A. S. Feliciano, J. M. S. Cabral, M. L. M.Serralheiro.
Portuguese Patent Number 102469, 2002.
Papers in Conference Proceedings
Anti-oxidant Activity of Hydroxy(thio)pyrone Iron-chelators
S. Chaves, S. Canário, M. Carrasco, L. Mira, M. A. Santos
Metal Ions in Biology and Medicine, John Libbey Eurotext, Vol. 10, Paris, 2008; pp. 000-006.
HOCl Produced by Human Neutrophils Scavenged by Flavonoids
M. Rodrigues, A. Freire, G. Justino, M. C. Monteiro, L. Mira
European Meeting of the Society for Free radical Research International, Medimond Vilamoura, Portugal, 2007; pp 137-140.
Antioxidant Activity and Characterization of Compounds from Cynara Scolymus, Cactus Grandiflorus and Sangre de Drago by SPME/GC-MS.
S. Amaral , M. L. Mira, J. M. F. Nogueira, M. H. Florêncio.
Advances in Mass Spectrometry; Vol. 16 (A. E. Ashcroft, G. Brenton, J. J. Monaghan, Editors); Elsevier: Amsterdam, 2004; CD-ROM supplement, 113.
Study of the Volatile Fraction of a Few Medicinal Plants by SPME/GC-MS.
S. Amaral, L. Mira, J. M. F. Nogueira, M. H. Florêncio.
Proceedings of the 27th International Symposium on Capillary Chromatography, Analysis of Natural Products, Food, Flavours and Fragances; Riva del Garda, 2004, P.32; CD-ROM.
Pedagogic publications
Teaching of Biotechnology in the Biochemistry Course.
M. L. M. Serralheiro, A. Ponces Freire.
Electronic Journal of Biotechnology 2002, 5, 212-215.
Formação Intracelular de Espécies Reactivas de Oxigénio e de Azoto e Sistemas de Defesa Antioxidantes.
L. Mira.
Associação de Estudantes da FCUL: Lisboa, 2004.
Uso das espécies Reactivas de Oxigénio em Processos Fisiológicos Úteis para a Célula.
L. Mira.
Associação de Estudantes da FCUL: Lisboa, 2004.
Doenças Associadas com o Stress Oxidativo.
L. Mira.
Associação de Estudantes da FCUL: Lisboa, 2004.
Outreaching activities
Teaching of Biotechnology in the Biochemistry Course.
M. L. M. Serralheiro, A. Ponces Freire.
Electronic Journal of Biotechnology 2002, 5, 212-215.
Níveis de Mercúrio Total em Espécies de Aquicultura.
H. M. Lourenço, M. F. Martins., A. R. Lino, M. L.Nunes.
In: Produtos da pesca. Qualidade, Segurança e Inovação Tecnológica, Actas das Jornadas Técnicas e Científicas do IPIMAR. Publicações avulso do IPIMAR, 2002, 9, pp 239-242.
As Bactérias Redutoras de Sulfato e a Corrosão Microbiológica.
M. J. Feio, A. Martins, I. Fonseca, A. R. Lino, M. Meireles.
Ciência 2000, Série VII (1), 3-8.